Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice
نویسندگان
چکیده
منابع مشابه
Gadd45a regulates hematopoietic stem cell stress responses in mice.
Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, following 5-fluorouracil treatment, Gadd45a(-/-) HSCs exhibited a faster recove...
متن کاملHEMATOPOIESIS AND STEM CELLS Gadd45a regulates hematopoietic stem cell stress responses in mice
• Loss of Gadd45a enhances HSC reconstitution on hematopoietic stress. • Gadd45a regulates DNA damage responses in HSCs. Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia.However, the functionofGadd45a inhematopoietic stemcells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a) mice showed a normal hematologic phenotype under h...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2014
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-013-0017-9